The college enrolls approximately 3,600 students and offers undergraduate and graduate programs through three schools in business, liberal arts, and science.

[12] Siena College offers more than 40 majors, 80 minors and certificates, and graduate programs in business, education, and other fields.

[15] Siena has various housing options, including traditional residence halls, private rooms, and townhouse units, across eight residential communities.

[17] Siena offers 21 NCAA Division I sports, all of which participate in the Metro Atlantic Athletic Conference (MAAC).

The Saints advanced to the 1999 NCAA Division I baseball tournament and in 2005 saw pitcher John Lannan drafted by the Washington Nationals.