It is a trematode, and being part of the genus Schistosoma, it is commonly referred to as a blood-fluke since the adult resides in blood vessels.

The eggs of Schistosoma intercalatum have a terminal spine and tend to be moderately larger than those of S. haematobium (approximately 130 × 75 μm).

[3] When viewed using scanning electron microscopy, it can be observed that the S. intercalatum's surface has a much lower amount of integumental elevations, or bosses, than S. mansoni.

If there is a small temperature change, the cercariae of S. intercalatum will form concentrated aggregates near the surface of the water.

[7] S. intercalatum is at risk of endangerment in large part due to the introduction of invasive species into its native habitat.

While crosses with S. mansoni give no viable offspring, the pairing with a male S. haematobium will result in a hybrid organism.

Most hybrids will have a diluted genome that is more closely related to S. haematobium, helping to bring about a decline in S. intercalatum populations.

The cercariae are very particular over where they develop, needing small, forested areas with streams to infect their human host.

[citation needed] Symptoms of all forms of schistosomiasis are caused by the immune system's reaction to the eggs, rather than the adult worms themselves.

[5] A few hours to days after cercariae invade the skin, some people experience pruritus and raised papules at the site of penetration.

Clinical presentation of an established S. intercalatum infection can be different in the local population and non-immune tourists.

This can only take place 6 to 8 weeks after initial infection in order for the parasite to reach the adult stage and the immune system to produce antibodies against it.

Administering treatment at the correct time is important since the drug only works against the adult worm and there must be a strong antibody response from the immune system.