Schreiner University now hosts a number of lecture series and academic conferences, including its annual popular culture symposium.

The school will add endowed chairs in mathematics, science, and humanities and hire a visiting artist and performer or designer in residence.

Schreiner University sports teams participate as a member of the National Collegiate Athletic Association (NCAA)'s Division III.

Men's sports include baseball, basketball, track and field, cross country, golf, soccer and tennis; while women's sports include basketball, track and field, cross country, golf, soccer, softball, tennis and volleyball.

Wrestling was added for the start of the 2018-19 year, only the second program in the state after Wayland Baptist University and the first in the NCAA.

Greek life had been unofficially established on campus earlier, on February 21, 2001, when Chi Phi fraternity founded a colony at Schreiner University; however, the colony was not chartered into the Iota Theta chapter of the Chi Phi fraternity until 2005.