The station is located at the Boston end of the Charles River Dam Bridge at Leverett Circle.

With 873 daily boardings by a FY 2019 count, Science Park is the least-used fare-controlled station on the Green Line, and the second-lowest on the MBTA subway system after Suffolk Downs.

Science Park station is elevated above Leverett Circle, where the Charles River Dam Bridge meets Storrow Drive at the north corner of the West End neighborhood.

Each platform has one elevator connecting it to street level and to the paid area of the main fare lobby, making the station accessible.

[2]: 2.10–16  With 873 daily boardings by a FY 2019 count, Science Park is the least-used fare-controlled station on the Green Line, and the second-lowest on the MBTA subway system after Suffolk Downs.

[9] A bill authorizing and directing the MTA to construct the station was signed by then-governor Christian Herter on April 29, 1954.

[16] The Metropolitan District Commission constructed a footbridge across Storrow Drive (opened in 1951) in 1955 at a cost of $120,000 (equivalent to $1.08 million in 2023).

The station was closed from June 25, 2004, to November 12, 2005, while the Causeway Street elevated was replaced by a new tunnel under TD Garden.

[19][22] The footbridge over Leverett Circle was removed in 2005 as part of Big Dig construction (to allow for the addition on an underpass to Storrow Drive), though the state promised to replace it.

[25] On January 21, 2009, station signage was changed to read "Science Park/West End", though MBTA maps continued to use the shorter name.

[19] On May 24, 2020, service between North Station and Lechmere was temporarily replaced with shuttle buses due to Green Line Extension construction.

[35] The Green Line was closed between Union Square and Government Center from August 22 to September 18, 2022; the closure allowed for final integration of a second northern branch, elimination of a speed restriction on the Lechmere Viaduct, demolition of the Government Center Garage, and other work.