The Tokyo Institute of Technology and Tokyo Medical and Dental University signed an agreement to merge into one university in October 2022.

[4] On 19 January 2023, it was decided for the new university to use the name "Institute of Science Tokyo" (東京科学大学).

On 31 October 2023, the Japanese cabinet decided to amend the National University Corporation Act.

The former National University Corporation Tokyo Institute of Technology (国立大学法人東京工業大学) was renamed the National University Corporation Institute of Science Tokyo (国立大学法人東京科学大学), and the National University Corporation Tokyo Medical and Dental University (国立大学法人東京医科歯科大学) was dissolved at the same time.

After being passed by the National Diet of Japan, the amendment took effect on 1 October 2024.