It is located at the end of False Creek and features many permanent interactive exhibits and displays, as well as areas with varying topics throughout the years.

In 1977, Barbara Brink ran mobile hands-on exhibits known as the Extended I around British Columbia's Lower Mainland.

Later, the temporary Arts, Sciences & Technology Centre opened in downtown Vancouver on January 15, 1982, attracting over 600,000 visitors.

Donations from the federal, provincial and municipal governments, the GVRD, the private sector, foundations, and individuals contributed $19.1 million to build an addition to the Expo Centre, redesign the interior and fabricate exhibits.

[6] On July 29, 2020, the organization's board of governors announced that BC Liberal MLA from Surrey-White Rock, Tracy Redies, would be resigning her legislature seat and taking over as the CEO of Science World, from September 14, 2020.

[9] In January 2022, Science World entered a long-term partnership with Acuitas Therapeutics, developers of the lipid nanoparticle technology used in the Pfizer–BioNTech COVID-19 vaccine.

[10] In September 2022, Teck Resources announced a $650,000 donation to Science World to increase awareness of the antimicrobial properties of copper.

[15] In July 2021, Science World received a $50,000 grant from the Government of Canada in order to develop a programming series surrounding vaccines.