Scio College (/ˈsaɪ.oʊ/ SY-oh) was an institution of higher education in Ohio in the late 19th and early 20th centuries.

Parts of it merged into Mount Union College, while its pharmacy school merged with what would become the University of Pittsburgh School of Pharmacy.

The institution was first organized under the name Rural Seminary in 1857 at Harlem Springs, Ohio, as a Methodist Episcopal Church seminary.

This was to reflect its plan of having students only take classes in their major and nothing else.

This plan was abandoned in 1878 and the school adopted the name of Scio College, New Market Station having been renamed to Scio.