Its natural habitats are temperate shrubland, subtropical or tropical dry shrubland, subtropical or tropical dry lowland grassland, rural gardens, and urban areas.

It is mainly found quite close to the coast, but it ranges inland to Grahamstown, Kei Road, Stutterheim and Amatola Mountains.

The eastern leopard toad typically breeds in large, permanent, usually deep pools, and calls from floating vegetation.

The eastern leopard toad typically is a late-winter or spring breeder The eastern leopard toad is presumed to feed on a variety of arthropods in the wild.

In captivity specimens feed on crickets, grasshoppers, small mice, and lizards.