At the 1961 French Grand Prix, Scuderia Serenissima entered two cars – a Cooper for Trintignant and a De Tomaso for Giorgio Scarlatti.

At the 1966 British Grand Prix Bruce McLaren finished in sixth place, scoring one World Championship point.

Serenissima entered the 1962 24 Hours of Le Mans with two Ferrari 250, one driven by Joakim Bonnier and Dan Gurney, and one by Carlo Maria Abate and Colin Davis.

In 1966 Serenissima joined forces with Luigi Chinetti's North American Racing Team and fielded one car at the 24 Hours of Le Mans driven by Vaccarella and Mario Casoni.

In 1968, Volpi got interested in the idea of building a proper GT car with the help of Alejandro de Tomaso's Ghia Studios.

The Ghia coupe, designed by Tom Tjaarda and Giorgetto Giugiaro, was originally fitted with a Massimino 3.5-litre V8 engine but later switched to a 3.0L Alf Francis M176 V8.