The Confraternity built the Scoletta in 1427 and it was expanded in 1504 with the Sala Priorale (Prior's Room) decorated with a cycle of fifteen frescoes and three canvases, which were worked on by the young Titian between 1510 and 1511.
The three large frescoes were painted by him between April and December 1511 in the main room of the Scuola del Santo – they were is first large-scale independent work.
To the left of the entrance to the church is the neoclassical marble gravestone of Gasparo Gozzi, who died in 1786 – it was sculpted by Giuseppe Petrelli in 1834.
In 1736 the architect Giovanni Gloria built a small building linking the Scuola to the Oratory, with an elegant staircase connecting it to the meeting room.
On the landing is a 15th century tempera on panel painting by an unknown artist showing St Anthony Intending to Write, in poor condition.