Sea anemone neurotoxin

A number of proteins belong to the sodium channel toxin family, including calitoxin and anthopleurin.

The neurotoxins bind specifically to the sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mammalian cardiac muscle contraction.

Calitoxin 1 has been found in neuromuscular preparations of crustaceans, where it increases transmitter release, causing firing of the axons.

[6] Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure.

[6] The potassium channel toxin family include kaliseptine and kalicludines,[8] and was also isolated from Anemonia viridis.