His voice acting credits include Luan's boyfriend Benny in The Loud House, Yumyulack Opposites Jr. in Solar Opposites, Jeff Randell in Clarence, Russell in Russell Madness, and Jimmy McGill in Slippin' Jimmy.

Giambrone was born in St. Joseph, Michigan[2] to a family of Italian and German descent,[3] and raised in Park Ridge, Illinois, where he attended Lincoln Middle School and Maine South High School.

As of 2019[update], he is based in Los Angeles, but often visits Park Ridge.

[4][5] Giambrone started his acting career at age nine, starring in television commercials for McDonald's and Friendly's Restaurants, among others.

From 2014 to 2018, Giambrone provided the voice of Jeff Randell, the title character's best friend, on the Cartoon Network animated series Clarence.