[citation needed] He has directed plays at the Donmar Warehouse, the Old Vic, the Royal Court and other London theatres, including The Entertainer, The English Game, The Man Who Had All the Luck, The Price, Look Back in Anger, Moonlight and Magnolias and Pornography.
[citation needed] He directed the new stage adaptation of Treasure Island, starring Keith Allen, which opened at the West End's Theatre Royal Haymarket in November 2008.
He directed a revival of Joe Orton’s Loot, starring Matt Di Angelo, at the Tricycle Theatre from December 2008.
[citation needed] In October 2008, it was announced that Holmes would take over from David Farr as artistic director of the Lyric Hammersmith in spring 2009.
"[2] In 2011, the Lyric Hammersmith won the Olivier Award for Outstanding Achievement in an Affiliate Theatre for Holmes' production of Sarah Kane's Blasted.