He was a long-time member of ACT UP New York and, in 1992, produced an off-Broadway play, The Night Larry Kramer Kissed Me, written by and starring David Drake.
In 2014, Strub criticized National Institute of Allergy and Infectious Diseases (NIAID) director Anthony Fauci for "delaying promotion of an AIDS treatment that would have prevented tens of thousands of deaths in the first years of the epidemic."
In 1981, Strub got playwright Tennessee Williams to sign the first fundraising letter for the Human Rights Campaign Fund, a then-newly formed political action committee which grew to become the largest organization in the U.S. advocating for LGBT equality.
[27] In 1989, Strub asked pop artist Keith Haring to create a logo and poster to launch National Coming Out Day, now also a part of the Human Rights Campaign.
[28] Strub was one of the AIDS activists who put a giant condom over then-US Senator Jesse Helms's suburban Washington home in 1991.