(2000), Road Trip (2000), Final Destination (2000), Evolution (2001), The Rundown (2003), The Dukes of Hazzard (2005), Mr. Woodcock (2007), Role Models (2008), and The Wrath of Becky (2023).

He also reprised his film voice role as Crash in two Ice Age television specials: A Mammoth Christmas (2011) and The Great Egg-Scapade (2016).

Early in his career, Scott worked at The Home Depot and the Los Angeles Zoo to support himself between acting jobs.

In 1996, Scott made his first on-screen appearance as Moondoggie on The WB's sitcom Unhappily Ever After in the episode "Beach Party."

[16][17][18]In 2017, Forbes reported that the American Pie films have grossed $989.5 million at the worldwide box office, became a pop culture phenomenon and made several cast members famous.

Scott's fear of typecasting led him to play different types of characters post-American Pie, such as a hapless nerd in the horror film Final Destination (2000) and a friendly stoner in Dude, Where's My Car?

[20] He also appeared in films Road Trip (2000), Jay and Silent Bob Strike Back (2001), Evolution (2001), Stark Raving Mad (2002) and Bulletproof Monk (2003).

[21] He played Peppers in Old School (2003), which was a moderate box office success and has gained a massive cult following over the years.

[23] He was nominated for MTV Movie Award for Best On-Screen Team with Jessica Simpson and Johnny Knoxville for their roles in The Dukes of Hazzard.

[24] Scott landed a lead role as a police officer in Southland Tales (2007), where he reunited with Dwayne "The Rock" Johnson, with whom he had previously worked in The Rundown (2003).

To get a chance to play a totally different character—because he's just a good, average, relatable guy going through obviously an awful moment in his life—was great," Scott told Variety.

[37][38] Executive producer of Bloodline Emma Tammi praised Scott's performance and acting skills by saying: "He has an amazing theater background and is a very versatile actor, and I don't think most of the world has seen that yet.

"[39] In May 2018, it was announced that Scott was cast as the new series lead in Fox's Lethal Weapon as a new character named Wesley Cole, replacing Clayne Crawford as Martin Riggs, who was fired amidst reports of bad behavior and incidents of hostility.

[43] Scott portrayed abusive stepfather Martin in the coming-of-age road film Already Gone (2019), which was executive produced by Keanu Reeves.

[49] From June to July 2023, Scott and his American Pie co-star Jason Biggs appeared in food delivery company DoorDash's "Summer of DashPass" campaign, including a television commercial.

[55] In March 2012, Scott confirmed that he had proposed on Valentine's Day[56] and became engaged to fashion model Lindsay Frimodt.