[19] On 21 November 2014, Petro Poroshenko Bloc, People's Front, Self Reliance, Fatherland and the Radical Party signed a coalition agreement.

[21] On 2 December 2014, Ukrainian president Petro Poroshenko granted citizenship to Natalie Jaresko, Alexander Kvitashvili and Aivaras Abromavičius, who were all potential ministers in the government.

Radical Party left the coalition on 1 September 2015 in protest over a vote in parliament involving a change to the Ukrainian Constitution that would lead to decentralization and greater powers for areas held by pro-Russian separatists.

[28] February 2016 saw the start of the fall of the cabinet after economy minister Aivaras Abromavičius announced his resignation claiming the government did not have a real commitment to fight corruption.

[31] Self Reliance then (also on 17 February 2016) issued an official statement on its Facebook page in which it argued "A cynical coup has occurred in Ukraine, with the help of the president, the prime minister, the kleptocratic part of the coalition, and the oligarch bloc" that led to the second Yatsenyuk government being an "illegitimate government".

"[11] On 25 March 2016 Parliamentary Speaker Volodymyr Groysman had been nominated by coalition partner Petro Poroshenko Bloc to replace Yatsenyuk.

On 2 December 2014, President Petro Poroshenko proposed that the Verkhovna Rada reappoint Pavlo Klimkin and Stepan Poltorak for these posts.

[28] On 2 July 2015, the Minister of Ecology Ihor Shevchenko was fired by parliament because "[the ministry] doesn't fulfill its basic functions and obligations".

[39] During the lifespan of the second Yatsenyuk Government the Cabinet Ministers of agriculture, health and information Oleksiy Pavlenko, Alexander Kvitashvili and Yuriy Stets all announced and later withdrew their resignations.

[42] On 4 February 2016 leader of Self Reliance parliamentary faction Oleh Berezyuk stated that Pavlenko no longer represented his party in the second Yatsenyuk Government.

[44] Economy minister Aivaras Abromavičius announced his resignation on 3 February 2016 claiming the government did not have a real commitment to fight corruption.