4KEG, 4KGH, 4KGO, 4N4X, 5I7K, 5I7J, 5I7L5129718843ENSG00000198183ENSMUSG00000027483Q9NP55P97361NM_001243193NM_016583NM_130852NM_011126NP_001230122NP_057667NP_570913NP_035256BPI fold containing family A, member 1 (BPIFA1), also known as Palate, lung, and nasal epithelium clone (PLUNC),[5] is a protein that in humans is encoded by the BPIFA1 gene.

[8] The protein can be detected on the apical side of epithelial cells and in airway surface liquid, nasal mucus, and sputum.

[11] The BPI fold creates apolar binding pockets that can interact with hydrophobic and amphipathic molecules, such as the acyl carbon chains of lipopolysaccharide found on Gram-negative bacteria, but members of this family may have many other functions.

BPIFA1 has multiple functions but perhaps its most prominent ones are related to BPIFA1's localization in nasal, olfactory, oral, and respiratory epithelium and the mucous/fluids that coat them.

[21] Thus, defective BPIFA1/PLUNC1 gene function is thought to contribute to the development of lung pathology in cystic fibrosis patients.