Sedini (Sassarese: Séddini) is a comune (municipality) in the Province of Sassari in the Italian region Sardinia, located about 180 kilometres (110 mi) north of Cagliari and about 25 kilometres (16 mi) northeast of Sassari.

It is part of the Anglona traditional subregion.

Sedini borders the following municipalities: Bulzi, Castelsardo, Laerru, Nulvi, Santa Maria Coghinas, Tergu, Valledoria.

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