Semestene is a comune (municipality) in the Province of Sassari in the Italian region Sardinia, located about 140 kilometres (87 mi) north of Cagliari and about 40 kilometres (25 mi) southeast of Sassari.

As of 31 December 2004, it had a population of 206 and an area of 39.8 square kilometres (15.4 sq mi).

[3] Semestene borders the following municipalities: Bonorva, Cossoine, Macomer, Pozzomaggiore, Sindia.

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