It forms part of the Furka Oberalp Bahn (FO), which connects Brig in Valais, via Andermatt in Uri, with Göschenen, Uri, and, via the Oberalp Pass, with Sedrun and Disentis/Mustér, Graubünden.

The MGB operates regional services between Andermatt and Disentis/Mustér via Sedrun, at hourly intervals.

They also connect in Disentis/Mustér with similar hourly regional services, operated by the Rhaetian Railway and heading further east.

[1] Additionally, during the winter closure of the Oberalp pass road, the MGB also operates frequent car shuttle trains between Andermatt and Sedrun, via the Oberalp Pass.

[2][3] Every day several Glacier Express trains pass through Sedrun, but do not stop there.