They have experienced continued success with many number one hits on the Hot Mainstream Rock Tracks chart, such as "Remedy", "Fake It", "Country Song", "Tonight", "Words as Weapons", "Let You Down", "Dangerous", "Bruised and Bloodied", and "Wasteland".

[2] Consisting of frontman, vocalist, and guitarist Shaun Morgan, bassist Tyronne Morris (who left the band in December 1999 and was replaced by Dale Stewart in January 2000), and drummer Dave Cohoe, the band released their first album, Fragile, in October 2000 under Johannesburg-based independent record label Musketeer Records.

[2] Upon signing to the label, they were told they needed to change their name due to its similarity to sarin gas, and switched to calling themselves Seether, after the Veruca Salt song.

[3] In August 2002, Seether launched their first official album, Disclaimer, which earned the band three singles: "Fine Again", "Driven Under", and "Gasoline", in which only the first managed significant success.

Following the release of Disclaimer, the band toured continually in order to increase sales and gain name recognition.

A planned second album was delayed for nearly a year when Seether was selected as the support act for an Evanescence worldwide tour.

Favourable audience response led the band to record the revised version, with Lee on vocals.

[4] An alternate version of the original album, with many of its songs remixed or re-recorded, was released in June 2004 and entitled Disclaimer II.

Seether released an acoustic CD/DVD set titled One Cold Night, recorded at the Grape Street Club in Philadelphia, on 22 February 2006.

Finding Beauty in Negative Spaces was slated for an August 2007 release but was delayed until 23 October 2007 due to the suicide of Morgan's brother, Eugene Welgemoed.

Troy McLawhorn of Dark New Day, Evanescence, and doubleDrive was hired as a touring guitarist on 15 February 2008.

Bands Seether shared the stage with on the tour included Three Days Grace, Finger Eleven, Breaking Benjamin, 3 Doors Down, Skillet, Red, Papa Roach, Flyleaf, Econoline Crush, and Staind.

"No Shelter" appeared on the NCIS Official TV Soundtrack, released on 10 February 2009, and a version of George Michael's "Careless Whisper" was made available for purchase as a digital or mobile download.

The music video for "Careless Whisper" premiered on 15 June 2009, and the song is included as an additional track on the reissue of Finding Beauty in Negative Spaces.

Shaun and Dale confirmed in an interview on 2 March 2009 that, after the Nickelback tour, Seether would take the rest of year off to write and record the follow-up to Finding Beauty in Negative Spaces.

[11] The band nevertheless gave performances through the remainder of the year, which included a date in Okinawa to play for American troops as part of a USO tour on 23 and 24 May at Camp Schwab, and then in MCAS Iwakuni on 26 May for the US Marines.

[17][18] McLawhorn and Humphrey, in a radio interview, announced that the new album would be titled Holding Onto Strings Better Left to Fray, and that it would be released in May.

[26] The band played main stage at the Uproar Festival alongside Avenged Sevenfold, Three Days Grace, Bullet For My Valentine, and Escape The Fate, and supported 3 Doors Down on their European tour from November to March.

On 30 November 2013, Seether released a 3-track single titled "Goodbye Tonight", featuring Van Coke Kartel & Jon Savage.

[33][34] On 17 May 2014, Seether performed their first single, "Words as Weapons," from the album Isolate and Medicate, live at the Orbit Room in front of 1,700 fans.

In late May and early June, Seether announced European tour dates in September, along with several stops in the UK.

[36] They then recorded a cover of "Black Honey" by American post-hardcore band Thrice during a live session for SiriusXM in June 2017.

On 24 June 2020, the band announced their eighth studio album, Si Vis Pacem, Para Bellum, set for release on 28 August 2020 through Fantasy Records.

[39] Translating to "If You Want Peace, Prepare for War", the album features 13 new tracks, and was produced by Morgan himself in Nashville, Tennessee from December 2019 to January 2020.

[51] Si Vis Pacem, Para Bellum in particular takes heavy influence from the bands A Perfect Circle and Deftones.