Segerseni was an ancient Egyptian or Nubian chieftain of Nubia, likely reigning concurrently with the end of the 11th and beginning of the 12th Dynasty during the early Middle Kingdom.

Segerseni is attested by one[3] or two[4][5] rock inscriptions discovered in Umbarakab (Khor-Dehmit) in Lower Nubia.

Segerseni's throne name as given on the inscriptions remains in doubt as it was roughly carved and became badly weathered over time.

If Segerseni was indeed Amenemhat I's foe, he could have been fighting on Mentuhotep IV's side or for his own Nubian realm.

Indeed, Nubia had gained its independence during the First Intermediate Period, as indicated by the military campaigns of Mentuhotep II in the region, only 40 years prior to Segerseni's conjectured lifetime.