Segundo Cardona Colom FAIA (born 1950) is a Puerto Rican architect and developer.

Cardona entered the School of Architecture of the University of Puerto Rico and was a member of its first graduating class, obtaining a B.Arch in 1972.

He was a design professor in the UPR (1974–1984) and was principal at Segundo Cardona Architects before co-founding in 1984 Sierra Cardona Ferrer (now known as SCF Architects) with partners Luis Sierra and Alberto Ferrer.

[5] In 2013, Cardona won a competition to rebuild the Cathedral of Our Lady of the Assumption, Port-au-Prince, Haiti.

[6] In 2017, he participated in the UIA World Architects Congress in Seoul and received the Public Space Award for his design of the Paseo Puerta de Tierra, a promenade that connects two important tourist destinations in Puerto Rico.