Located in the northern part of the province, it is centered on the town, and municipal seat, of Mayarí Arriba.

The municipality is located north of the province, neighboring the provinces of Holguín and Guantánamo; and is partly included into Sierra Cristal National Park's territory.

It borders with the municipalities of Mayarí, Frank País, Sagua de Tánamo, El Salvador, Songo-La Maya and San Luis.

It includes the town of Mayarí Arriba and the villages of Boca de Micara, Loma Blanca, Sabanilla, San Benito de Mayarí, Soledad and Tumba Siete.

Media related to Segundo Frente at Wikimedia Commons