Seisen University (清泉女子大学, Seisen Joshi Daigaku) is a private Catholic liberal arts women's college in Shinagawa, Tokyo, Japan.

The predecessor of the school, Seisenryōgakuin (清泉寮学院), was founded in 1938 by the Handmaids of the Sacred Heart of Jesus.

It was chartered as a women's four-year college in 1950.

3-16-21 Higashi Gotanda, Shinagawa-ku, Tokyo, 141-8642, Japan The university's Italian Renaissance style main building designed by Josiah Conder was built as Prince Shimazu Tadashige's mansion in 1917.

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