Originating from the Monti Picentini in Caposele,[1] it flows through the region of Campania, in the provinces of Salerno and Avellino.

Its mouth is in the Gulf of Salerno, on the Tyrrhenian Sea, at the borders between the municipalities of Eboli and Capaccio (not too far from Paestum), in the beginning point of Cilentan Coast.

The important Greek site of Foce del Sele, a sanctuary complex dedicated to the goddess Hera, is at the ancient mouth of the river, though little remains on the site; the relief friezes and other finds are now in the museum at Paestum.

At this period the Sele represented the border of the Greek and Etruscan zones of influence along the coast.

The municipalities crossed by the river, from the mouth to the origin, are Eboli, Capaccio, Albanella, Serre, Campagna, Contursi Terme, Oliveto Citra, Colliano, Senerchia, Valva, Calabritto and Caposele.