Ndèye Binta Diongue earned a spot in the women's épée by winning the African Zonal Qualifier in Cairo, Egypt.

2019 African Games champion Mbagnick Ndiaye received a continental berth from Africa as the nation's top-ranked judoka, outside of a direct qualifying position in the IJF World Ranking List as of June 28, 2021.

[5][6] For the first time since Los Angeles 1984, Senegal received an invitation from ISSF to send Italian-born Chiara Costa in the women's skeet, if the minimum qualifying score (MQS) was fulfilled by June 6, 2021.

[7] Senegal received universality invitations from FINA to send two top-ranked swimmers (one per gender) in their respective individual events.

[9] Senegal qualified one wrestler for the men's freestyle 65 kg event, by progressing to the final at the 2021 African & Oceania Qualification Tournament in Hammamet, Tunisia.