Its administrative headquarter is located in Sengerema city.

[4] It is bordered to the north and east by Lake Victoria, to the south by Geita Region and to the southeast by the Misungwi District.

In 2016 the Tanzania National Bureau of Statistics report there were 377,649 people in the district, from 663,034 in 2012.

[5]: 147 [6]: 178 Sengerema District is divided into 3 divisions, 26 wards, 71 villages and 421 hamlets (vitongoji).

As of the 2010 elections Sengerema District had two constituencies:[8] Ward (2016 Population)[5]: 147