Produced by the non-profit Mobile Arts & Sports Association,[1] the game is also a charitable fund-raiser, benefiting various local and regional organizations with over US$7.8 million in donations over its history.

Starting with the 2021 edition, the game is played at Hancock Whitney Stadium on the campus of the University of South Alabama, also in Mobile.

[16] In October 2020, Panini America entered a multi-year agreement to produce trading cards for Senior Bowl players.

In 1991, team names were changed to AFC and NFC,[18] to distinguish where their coaching staffs were from and to stress the professional nature of the game.

This was somewhat confusing, as the Senior Bowl is played early in the calendar year, typically several months before players are selected by teams in the NFL draft.

Beginning with the 2022 edition, head coaches serve in more of an advisory capacity while promoting select assistants into leadership roles on the staff.

[20] Organizers stipulate a number of specific rules for the game, some of which are intended to reduce the chance of injury (e.g. "All blocks below the waist are prohibited"), and others that simplify what the teams need to practice and prepare for (e.g. "Only four rushers allowed, no 5-man pressures or blitzes from secondary permitted").

The week-long practice that precedes the game is attended by key NFL personnel (including coaches, general managers and scouts), who oversee the players as possible prospects for professional football.

Athletes sometimes decline invitations to participate in the Senior Bowl, opting instead to prepare for the NFL scouting combine or their college's pro day.

[23] Dan Lynch of Washington State was the first (and to date only) player to appear in two Senior Bowls (1984 and 1985), having been granted an extra year of eligibility after the 1984 game.

[24] In 2013, two players (D. J. Fluker and Justin Pugh) with a year of college football eligibility remaining, but who had already graduated, became the first "fourth-year juniors" to be granted clearance to play in the Senior Bowl.