A 16-year-old genius named Senku Ishigami is suddenly revived to find himself in a world where all traces of human civilization have been eroded by time.

In the anime adaptation of the series he is voiced by Yūsuke Kobayashi in Japanese and Aaron Dismuke in the English dub.

Critical response to Senku's character has been positive, appearing in multiple polls of popularity and winning the 4th Crunchyroll Anime Awards of Best Protagonist of the Year.

"[5] In regards to the series' message, Inagaki wanted readers to understand Senku's "power" and his ambitions, using his knowledge of the past to make a stronger future.

After awakening in the "Stone World", he sets to restore civilization by reinventing their lost technology and discovering a "cure" for the petrification.

Though somewhat arrogant, he is actually very noble and kind-hearted as he considers science as a means to elevate all people and having unshakeable faith in his friends.

Following Hyoga's defeat and Tsukasa entering cryosleep, Senku was able to get the remnants of the Empire of Might to merge with the Kingdom of Science where he leads the Five Wise Generals.

[14] In 2022, he was also nominated at the 6th Crunchyroll Anime Awards in the "Best Boy" category, for his role in the Stone Wars season of Dr.

[17] Anime UK News found his design impressive, comparing him to Yugi Mutou's hair, and felt that Senku's quest to restore modernity seems possible.

[19] The same website made an entire article centered around Senku, calling him "a hero at heart though, not the reclusive, eccentric Dr. Frankenstein type" with derivations form little pleasure or meaning from deep personal connections.

[20] Writers have commented on Senku's relationships portrayed in the narrative, most notably the members from Ishigami Village and his rivalry with Tsukasa.

Initially, Manga.Tokyo said that the dynamic between Senku and Taiju was similar to Pinky and the Brain series and found that the duo has interesting interactions.

[21] Anime UK News also saw Senku's quest to increase the firepower of the Ishigami Village as a build up to the eventual second season which explores the fight against Tsukasa's forces.

[23][24][25] Senku's rivalry with Tsukasa was also the focus of the series' themes involving science against strength, with Medium website regarded the second anime season as the most important parts it adapted.

[27] Comic Book Bin enjoyed the clash in the ninth volume between such forces to the point of calling it the best part of the manga.

[29][30] In an article by the Japanese AnimeAnime website, Senku was listed as the second best Kobayashi character behind Subaru Natsuki from Re:Zero − Starting Life in Another World.