After the petitions of their seven year-old son, Salvador, the couple is set to marry when a group of hitmen attacks the wedding and murders Vicente.

However, the president of Mexico sentences Sara to 25 years in prison at the request of his private secretary Berta Aguilar (Luciana Silveyra).

The hatred of a resentful sister, the political ambitions of a corrupt president, and other twists of destiny cause Señora Acero to fall into the hands of her mortal enemy, El Teca Martinez.

For the second time, Sara must say goodbye to her son, Salvador (Michel Duval) and the great love of her lie, Manuel Caicedo (Lincoln Palomeque).

Vicenta is also one of the most wanted women by Homeland Security, particularly by officer Daniel Phillips (Luis Ernesto Franco), and other coyotes, who are threatened by her dominance in the business.

Vicenta's journey is complicated by Governor of Chihuahua, Chucho Casares (Sergio Goyri), who is her mother's murderer and one of the heads of the most powerful arms trafficking rings in northern Mexico.

In season four, Vicenta Acero is wanted by the governments of Mexico and the United States as her family is the main suspect in the death of Governor Chucho Casáres.

In addition, Colombian drug trafficker Julián Romero (Diego Cadavid) arrives in Mexico to avenge the death of his relatives and his mother, Briceida Montero.

Sandra Echeverría was originally planned to star, but Blanca Soto was selected to play protagonist Sara Aguilar.