[1] Sentinel cells represent diverse array of cell types with the capability to monitor the presence of exogenous or potentially harmful particles and play a crucial role in recognizing and sampling signs of infection or abnormal cellular activity and/or death.
[4] In elucidating the intricate network of phenotypic markers characterizing sentinel cells residing in skin there is a recent study offering an in-depth exploration whereas stimulus-specific gene expression and functions are described in the summarized article.
[5] Interestingly, novel function has been discovered by designing sentinel bacteria Bacillus subtilis combining the living organism with evolutionary function of sentinels resulting in surveillance of specific DNA sequences and reporting single nucleotide polymorphism associated with facial features through the mechanism by which these sentinel cells take up and record target DNA sequences, using CRISPR interference for SNP differentiation and expression of target gene.
This technology demonstrates potential applications in areas like forensics, ecology, and epidemiology, by enabling the detection of specific DNA sequences in various environments.
Application of such DNA-specific surveillance can be designed in detection of an anomaly and targeting the localized treatment to identified tissue such as tumor.