It flows through the mountainous Serra do Tapirapuã region and is a tributary of the Paraguay River.

The Sepotuba River's drainage basin is an area of over 984,000 hectares (2,430,000 acres) or 9,840 km2 (3,800 sq mi), representing about 1% of the total area of the state of Mato Grosso.

The Sepotuba River cuts through the Serra do Tapirapuã, a basaltic plateau with an average altitude of about 450 meters, until it reaches the lower altitudes of the Paraguay River.

Some of the most well known places are the Salto das Nuvens Waterfalls, with a height of 19 meters and a width of 100 meters, and the Salto Maciel Waterfalls, which forms a sequence of rapids.

This article related to a river in Mato Grosso, Brazil is a stub.