Septate junction

They are thought to provide structural strength and a barrier to solute diffusion through the intercellular space.

[1] Recent studies show that septate junctions are also identified in the myelinated nerve fibers of the vertebrates.

[2][3] The main trait of septate junctions structure is that cross-bridges or septa are in the ladder-like shape and cover the 15–20 nm intermembrane space of cell–cell contacts.

[10][11] There are three known claudins contained in the septate junctions, Megatrachea (Mega), Sinuous (Sinu) and Kune-kune (Kune).

Among these three claudins, Kune-kune (Kune) plays a more central role in septate junctions organization and function.