1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9887818412ENSG00000161011ENSG00000284099ENSMUSG00000015837Q13501Q64337NM_001142298NM_001142299NM_003900NM_001290769NM_011018NP_001135770NP_001135771NP_003891NP_001277698NP_035148Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene.

[5][6][7] Also known as the ubiquitin-binding protein p62,[8] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy.

By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.

[9] Mutations in SQSTM1 are a common cause of Paget's disease of bone.

[10] Sequestosome 1 has been shown to interact with: