[5] The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER).

This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair.

This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

[7] These polymerases have roles in the DNA damage tolerance pathway of translesion synthesis that allows the replication fork to continue without stalling even when damage is present.

[7] RAD23A has been shown to interact with: This article on a gene on human chromosome 19 is a stub.