[5] Sequoyah offers extracurricular activities which include Associated Student Body, 25+ school clubs, and various special interest organizations.

A partial list of organizations includes: Academic Incentive Club, Art Club, Beta Club, Color Guard, Chief's Club, Class Government, Drama, Envirothon, Ethics Bowl, FCA, FCCLA, FFA, FLC, FTA/Peer Tutoring, Future Business Leaders of America, GSA, HOSA, Journalism, Key Club, Music (marching band and concert choir), Planet Club, SACS, Scholar's Bowl, Science Bowl, Science Fair, Science Honor Society, Science Olympiad, Sequoyah Cares, SQHS government, Student Council, Talent Search, VICA, and Yearbook.

A few of these teams include football, basketball, marching band, cheerleading, and baseball, as well as many others.

In August 2011, allegedly after years of teenagers being bullied for their sexual-orientation, a group of Sequoyah High students in Madisonville, wanted it to stop.

However, when several students attempted to start a gay–straight alliance to address the harassment they were ordered to stop circulating a petition asking for the group to be permitted at the school.