The school, which was founded in August 1958, is located at the base of the San Gabriel Mountains, situated on 2.25 acres (9,100 m2) of property leased from the California Department of Transportation.

The original church was demolished in 1974 when Caltrans was planning to expand the 710 Freeway through the site, but the project remains unrealized due to community opposition.

In 2013, the campus was expanded by Los Angeles architecture firm, Fung + Blatt Architects.

Weaving into the existing mid-century campus fabric, Sequoyah's expansion echoes the spirit of the original architecture, while providing a sustainable, contemporary interpretation for a new generation.

The expansion was published in Architectural Record[2] and also won an honor award for design and a sustainability award by the AIA Pasadena & Foothills chapter [3] The high school campus is located on the grounds of the Neighborhood Church in Pasadena, adjacent to the historic Gamble House and within walking distance of playing fields in the Arroyo and the Rose Bowl Aquatic Center.