Bellarmine-Jefferson was a co-educational Catholic high school located in Burbank, CA that was founded by Monsignor Martin Cody Keating in 1944.

Keating selected the school's name from St. Robert Bellarmine (a 17th-century Italian Jesuit priest) and Thomas Jefferson (the nation's 3rd president).

The school's main building is a replica of the old Pennsylvania State House, also known as Independence Hall, located in Philadelphia, PA.

The main entry to St. Eleanor's Hall has 13 steps, representing the original 13 colonies in the order they became states by ratifying the U.S. Constitution.

As of the 2014-2015 school year the school offered eight Advanced Placement courses (Calculus, Chemistry, Chinese Language & Culture, English Literature, European History, Psychology, Spanish Language, and United States History), UC approved college prep courses, and a host of electives.

The boys team has made the CIF-SS playoffs six consecutive years and had California's state leader in scoring in 1998 in Ruben Douglas.

The Lady Guards proudly own the school's only two sectional championships, winning the CIF-SS title during the 1996-1997 season and most recently during the 2008-2009 campaign.

During the 2012 season Rishonda Napier was named the LA Daily News player of the year and was nominated as a McDonald's All-American.

The Lady Guards basketball team won the 2017 CIF-SS Division 5A Championship and advanced to the CIF Semi-Finals in the State Tournament.

Despite the school's small student population, the football team is consistently ranked in the top-ten of CIF-SS's Northeast Division.