Daniel Murphy High School was originally the home of Los Angeles College, a Catholic junior seminary.

During this time the school was renamed in honor of Daniel Murphy, a businessman and civic leader whose foundation made generous financial contributions to fund the construction of the new building.

In October 2007, it was announced that the school would close at the end of the 2007–2008 academic year due to declining enrollment.

[2] The timing of the closure coincided with the archdiocese's payoff of a $660 million settlement to abuse victims.

The parents proposed to pay an additional $1,000 per year in tuition which, they contended, would have exceeded any amount the archdiocese had ever had to spend to keep the school in the black.

[6] In April 2009, The Jewish Journal of Greater Los Angeles reported that the campus, located in the heart of the heavily Orthodox Jewish Fairfax District, had been sold to Yeshiva Aharon Yaakov-Ohr Eliyahu, an Orthodox day school currently located in Culver City.