During this time, Serajuddin Hossain wrote in the newspaper on behalf of the liberation war, and secretly helped the freedom fighters.

[2] In 1949, Hossain married Nurjahan Begum,[1] the sister of his college friend Shamsuddin Molla, who was to become a politician.

As editor of the Daily Azad, Moulana Akram Khan, asked him to publish a report which would disclose that the bond between the leaders and parties of the Jukto Front had broken.

As an honest journalist, Serajuddin Hossain published a report which was based on Jukto Front's press release.

Serajuddin Hossain wanted to establish the fact that it was an organised crime, a single group of many criminals.

[6][7] Hossain was a trade unionist as well, and was elected as the president of the East Pakistan Journalism Union for two terms.

Hossain agreed with Huseyn Shaheed Suhrawardy and Sheikh Mujibur Rahman's political point of view.

From 1969 to 1971, he wrote political propaganda against Ayub Khan, thereby playing an important role in the 1969 uprising in East Pakistan through his newspaper.

On the night 25 March 1971, the Pakistani army destroyed the Ittefaq office with a bomb because of its support of the Awami League.

In early December 1971, the Indian army joined with the Bangladesh freedom fighters in their battle against Pakistan.

On the night of 10 December, a number of Pakistani soldiers, along with members of Al-Badr and Razakar, captured him at his residence in Chamelibag, Shantinagar.

[1] On 3 November 2013, the International Crimes Tribunal – a special Bangladeshi court set up by the government – sentenced Chowdhury Mueen-Uddin and Ashrafuz Zaman Khan to death after the tribunal found him guilty in absentia of torture and murder of 18 intellectuals including Serajuddin Hossain during 1971 Liberation War of Bangladesh.