After the war, Serbia united with Montenegro and territories previously held by Austria-Hungary to create a unified South Slavic state that would come to be known as Yugoslavia.

During World War II in Yugoslavia, the United States initially supported the Serbian royalist Chetniks over their rivals, the communist Partisans.

On February 3, 1882, the Serbian Parliament adopted a contract and convention of diplomatic relations between the Kingdom of Serbia and the United States, given by King Milan Obrenović.

Wilson's tenth point asserted that the peoples living in Austria Hungary should independently decide their fates after the war, directly contradicting the British government's post-war vision of a surviving Austria-Hungary.

[9] During the negotiations for the Treaty of Versailles, the United States were represented by a delegation which was heavily involved in defining the borders for the new Kingdom of Serbs, Croats, and Slovenes.

During the process of defining new borders, The Kingdom of Serbia selected Jovan Cvijić to show maps to the American delegation in an effort to persuade them to endorse the acquisition of Baranya, east Banat, and other regions previously ruled by Austria Hungary, Bulgaria, and Romania.

Likewise, the American delegation also faced the lobby of Serbia's neighboring countries, and for the most part endorsed the allocation of Baranya to Hungary and most of Banat to Romania, in contrast to Cvijić's proposals.

In 1943, the US government's support for the Chetniks over the Yugoslav Partisans was such that president Franklin D. Roosevelt discussed with Winston Churchill in a private conversation that he imagined that Yugoslavia's boundaries would be completely redrawn into three separate states, with Peter II being the monarch of an independent Serbian kingdom at the end of the war.

At the end of the war, President Harry S. Truman dedicated a Legion of Merit to Chetnik leader Draža Mihailović, but the award wasn't revealed publicly until 2005.

[20] However, the request was shunned and early relations between the United States and the government of Josip Broz Tito became strained, as American diplomats were furious over Mihailović's execution in 1946.

[26] Following the Second World War into 1961, the United States operated a Military Assistance Advisory Group (MAAG) and many Yugoslavian officers received American training.

On 20 June 1979, a Serbian nationalist named Nikola Kavaja hijacked American Airlines Flight 293 from New York City with the intention of crashing the Boeing 707 into League of Communists of Yugoslavia headquarters in Belgrade.

[37] He eventually became one of the most feared gangsters in the New York City underworld, and developed extensive friendships with Vojislav Stanimirović, John Gotti and the Gambino family.

[38] As a result of this, Radonjić was arrested in December 1999 during a spectacular rerouted plane going to Cuba to a lockdown at Miami International Airport when he was tracked down by the FBI.

[52] The amendment officially came into legal effect from May 6, 1992; although it applied only to $5 million-worth of US foreign aid, it was reported as instrumental in denying SFR Yugoslavia its last application for IMF loans before its breakup and hyperinflation episode.

[63] In 1997, a group of 17 economists wrote a letter titled "Program Radikalnih Ekonomskih Reformi u Jugoslaviji", advocating liberal macroeconomic policy by creating alarming predictions of the Yugoslav economy from 1998 to 2010.

[73] A group named Otpor!, originally formed by students in 1998 with the financial assistance of USAID, International Republican Institute, and NED, was one of multiple significant participants in the Bulldozer Revolution, from which Milošević was overthrown.

[74] USAID donated over $30 million for Otpor to "purchase cell phones and computers for DOS's leadership and to recruit and train an army of 20,000 election monitors" as well as to supplement them with "a sophisticated marketing campaign with posters, badges and T-shirts.

[84] In March 2001, American economist Joseph Stiglitz traveled to Belgrade to talk to a prominent Democratic Opposition leader, Zoran Đinđić, about the potential consequences of IMF-sponsored austerity.

The G17 Plus got into an intense standoff with the Serbian government, composed mostly by DOS, due to the fact that G17 Plus continuously lobbied for the dissolution of the state union of Serbia and Montenegro.

In September 2002, it was announced that the Military Court in Belgrade was to press charges against Momčilo Perišić, who was the vice president of the Federal Republic of Yugoslavia at the time, for espionage in the favour of the CIA.

[91] The trial never took place, although upon his release from The Hague on February 28, 2013, it was announced by Perišić's lawyer Novak Lukić that his client was "ready to be judged" on the same 2002 accusations of espionage.

[94] Only a few days after this election result, the declaring of independence by Kosovo on February 17, 2008 spurred off widespread unrest in Serbia, during which the embassy of the United States was evacuated and then torched by a mob.

On July 3, 2012, the US government sent Philip Reeker to Belgrade, who participated in an undisclosed discussion with Mlađan Dinkić of the United Regions of Serbia party in his first day there.

[103] Reeker's meetings with the leaders of various parties shortly after the election resulted in speculation on the United States overtly forming a coalition in the Serbian government.

[106] Ahead of the 2016 presidential election in the United States, Vučić attended the Clinton Foundation's Global Initiative Annual Meeting held in September 2016.

[108] Subsequently, former Trump campaign consultant Roger Stone alleged on an InfoWars episode that the government of Serbia paid $2 million for attending the Clinton Foundation's meeting.

"[110] Vučić insisted that he was neutral in the US election in spite of his appearance at the Clinton Foundation meeting, adding that "Serbia is a small country to take sides of decisions made by Americans".

[125] Blue-chip American corporations making investments in Serbia include Coca-Cola, PepsiCo, Philip Morris, Molson Coors, Archer Daniels Midland, Goodyear, and Ball.

The United States is the primary partner of Serbia in the ICT industry, with likes of Microsoft, AMD, and NCR having their development centers in Belgrade.