It is also the highest regional league for the eastern part of Serbia.

The following 16 clubs compete in the Serbian League East during the 2023–24 season.

[2] The following is a list of clubs who have played in the Serbian League East at any time since its formation in 2006 to the current season.

Teams playing in the 2015–16 Serbian League East season are indicated in bold.

A total of 42 teams have played in the Serbian League East.