Before 1984 it was known as the Serbian Orthodox Eparchy of Eastern America and Canada.

The Holy Assembly of Bishops of 1991 ceded areas in South America to this diocese.

In South America and the Caribbean the Diocese of Eastern America has churches in Argentina, Brazil, Venezuela, Chile, Ecuador, Peru, and Dominican Republic.

[1] On May 26, 2011, by the decision of the Holy Council of Bishops of the Serbian Orthodox Church, parishes in South and Central America were allocated in the new Eparchy of Buenos Aires.

The diocese operates 58 churches and parishes and monasteries in the United States in Florida, Georgia, Maine, Massachusetts, New Hampshire, New Jersey, New York, North Carolina, Ohio, Maryland, Pennsylvania, Virginia and West Virginia.