The location of the hospital borders the South Klang Valley Expressway (SKVE) to the east and the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM) and the UPM own teaching hospital to the west.

It is designated as the reference center for cardiology, cardiothoracic, urology and nephrology surgery.

The hospital will provide affordable, quality treatment for heart patients from the lower income group.

The center will co-operate with the Hospital Selayang, which specialises in renal care and liver transplants.

The Heart Centre building of Sultan Idris Shah Serdang Hospital began operations on 12 December 2022.