Serenus came either from Antinoeia or from Antinoöpolis, a city in Egypt founded by Hadrian on top of an older settlement.
It was once believed that he was born in Antissa, but this has been shown to have been based on an error.
Serenus wrote a commentary on the Conics of Apollonius, which is now lost.
In propositions one though fifty-seven of On the Section of a Cone, Serenus deals largely with the areas of triangular sections of right and scalene cones that are created by planes passing through the vertex.
Propositions fifty-eight through sixty-nine form a separate section of the book and deal with the volumes of right cones in relation to their heights, their bases and the areas of triangular sections through the axis.