The Serial Experiments Lain video game, based on the anime of the same name, was released for PlayStation exclusively in Japan on November 26, 1998, by Pioneer LDC.

Throughout the game, the player, in the role of a therapist, unlocks pieces of information and multimedia with the assistance of the source material's protagonist, Lain Iwakura, to explore her mental state.

[1] As with the anime, the creative team's main goal was to let the player "feel" Lain, "to understand her problems, and to love her".

[7][8] A review of the browser version for The Michigan Daily described it as "raw and realistic in how it showcases mental health, but also overflowing with empathy for the matter, something a lot of representation misses.

[11] It received a 3/5 rating in a 2023 review from Grimoire of Horrror, which commented that players used to more traditional, linear forms of gameplay may prefer to experience the narrative by watching videos of the game due to its unconventional structure, also noting that compared to the anime it focused more on "alienation and how we crave human interaction".