The people of Serule Village comprises different ethnicities namely Bangwato, Bakwena, Batalaote, Bakalanga, Bahurutshe and its six wards are Mothoathubega, Borotsi, Mokwena, Botalaote, Basimaneng and Leupane.
The people of Serule are conservative and the majority of the village tend to lean towards the ruling Botswana Democratic Party.
Previous legislators who have represented Serule include former president Festus Gontebanye Mogae and former cabinet minister Lephimotswe Boyce Sebetlela.
Baratiwa Mathoothe of the opposition Botswana Patriotic Front is the Member of Parliament for Serowe North Constituency which covers Serule village.
Its strategic position along the country's main A1 road has led to the establishment of the Weight Bridge for trucks and other big vehicles in the early 2000s.
The village also host the Botswana Animal Information Traceability System (BAITS Cafe) operated by Imparo Holdings, a 100% citizen and youth owned company.
There is a high rate of harvesting of the seasonal caterpillar of a Mopane worm known as Phane (scientific name Gonimbrasia belina).
In 2007, BSE-listed A-Cap Resources, which has a prospecting licence covering 4, 500 square kilometres in the area, has announced the discovery of new uranium deposits in Serule Village, where drilling began in 2008.