It lies on the northern bank of the Zambezi River which forms the border with Namibia's Caprivi Strip at that point.

[1] The M10 road, which connects Sesheke to Livingstone and the Victoria Falls 200 km to the east,[2] was upgraded in 2004.

This 2500 km long asphalt road now connects Zambia's Copperbelt with Namibia's sea port (Walvis Bay).

[citation needed] Improved road access and the construction of new lodges and other tourist facilities have also increased the number of tourists passing through Sesheke on their way to the Victoria Falls, to the Sioma Ngwezi National Park 50 km west of the town, or to the upper Zambezi and the Barotse Floodplain.

[citation needed] The M10 road also connects Sesheke to Sioma, Senanga and Mongu 300 km north-north-west.