She traded with India, the Baltic, and Russia, carried troops for a Chilean military expedition against Peru, and transported convicts to New South Wales.

Sesostris first appeared in Lloyd's Register (LR) in 1818 with Thompson, master, Staniforth, owner, and trade Hull–Bengal.

British ships were then free to sail to India or the Indian Ocean under a license from the EIC.

[7] Reportedly her owners sold Sesostris for £6,300 after her first voyage, ship prices having collapsed.

On 24 September Sesostris, Porter, master, from Archangel, ran ashore in the River Thames at Deptford.

[12] In Valparaiso Sesostris was one of four merchant vessels that the Chilean Navy hired to carry troops and stores for an ultimately unsuccessful expedition to Peru.

Drake sailed Sesostris from Portsmouth on 30 November 1825 and arrived at Sydney on 21 March 1826.

Then on 11 October 1829, A. Yates, master and owner, sailed Sesostris on a second voyage to Bombay.